Stimulation of Maternal Behaviour in Rats with Cholecystokinin Octapeptide

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Cholecystokinin octapeptide inhibits carotid sinus baroreflex in anesthetized rats.

The purpose of this study was to determine the effect of cholecystokinin octapeptide (CCK-8) on carotid sinus baroreflex in 36 anesthetized male rats by isolated carotid sinus perfusion in vivo. The results obtained are as follows. (1) By perfusion with CCK-8 (0.1, 0.5, 1.0 micromol/L), the functional curve of baroreflex was shifted to the right and upward, with a decrease in peak slope (PS) (p...

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Electroacupuncture modulation of reflex hypertension in rats: role of cholecystokinin octapeptide.

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Synergistic effect of cholecystokinin octapeptide and angiotensin II in reversal of morphine induced analgesia in rats.

The aim of this paper is to study the synergistic anti-analgesic effect of angiotensin II (Ang II) plus cholecystokinin octapeptide (CCK-8). Our previous studies have shown that both CCK-8 and Ang II are potent anti-opioid substances. Intracerebroventricular (i.c.v.) injection of CCK-8 or Ang II dose-dependently antagonizes morphine-induced analgesia (MIA). In the present study, we observed the...

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Effect of cholecystokinin octapeptide on food intake in pigs.

Considerable interest has been aroused by the suggestion that the gut hormone cholecystokinin (CCK) is released during feeding and then acts as a satiety signal (Gibbs et al. 1973). Many studies, in species ranging from the mouse to man, have shown that peripheral administration of CCK, or its octapeptide, will reduce food intake. However, inhibition of feeding could be produced via a satiety s...

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Cholecystokinin octapeptide: a potential growth factor for pancreatic beta cells in diabetic rats.

CONTEXT Diabetes is associated with the reduction of beta cell mass and activity. Cholecystokinin (CCK) is known to induce growth of the exocrine pancreas and to stimulate insulin secretion. OBJECTIVE We investigated the possible role of CCK-octapeptide (CCK-8) in generating islet cell proliferation in type 1 and type 2 diabetic rats. METHODS Streptozotocin-induced type 1 diabetic rats, str...

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ژورنال

عنوان ژورنال: Journal of Neuroendocrinology

سال: 1989

ISSN: 0953-8194,1365-2826

DOI: 10.1111/j.1365-2826.1989.tb00135.x